This dataset includes a comprehensive suite of water-quality parameters, including alkalinity, organic alkalinity, dissolved inorganic carbon (DIC), short-lived radium isotopes (223Ra and 224Ra), stable isotopes (^13C and ^15N), dissolved organic carbon, and a broad range of organic contaminants (PAHs, alkanes, organochlorides, thiolates, PCBs, insecticides, pesticides, and herbicides). Samples were collected aboard the R/V Hogarth and R/V Weatherbird II during cruises in October 2022, January 2023, and March 2023 as part of the NSF RAPID (OCE-2309659) project following Hurricane Ian.